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Systemic effects of LLLT on bone repair around PLLA–PGA screws in the rabbit tibia

Lasers in Medical Science

Rodrigo Carvalho Pinto Coelho, Lívia Prates Soares Zerbinati, Marília Gerhardt de Oliveira, João Batista Blessmann Weber

11/1/2013 - 10.1007/s10103-013-1384-4
To evaluate the systemic effects of low level laser therapy (LLLT) on the early stages of bone repair after implantation of poly-l-lactic/polyglycolic acid (PLLA–PGA) screws 24 rabbits were randomly allocated to one of two groups, experiment or control. Each animal underwent implantation of one 5 × 1.5 mm PLLA–PGA screw in each tibia (right and left). The experiment group received infrared laser irradiation (830 nm, 4 J, 100 mW, 10.1 s) over the right paw immediately after implantation and every 48 h thereafter, for a maximum of seven sessions. The control group was not irradiated. Both groups were divided into three subgroups according to the observation period (5, 15, or 30 days), after which animals were euthanized. The results observed in the left paw of experimental animals were compared with the left paws of control animals. We also compared the right and left paws of experimental animals so as to compare local and potential systemic effects. Bone specimens were analyzed to assess the extent of peri-implant bone formation, quantitative analysis revealed greater bone formation in the left tibia of experimental animals as compared to controls on 5-day follow-up. Descriptive analysis revealed slightly larger and thicker trabeculae in the irradiated animals at 5 days post-procedure. There were no significant differences at any other point in time. As used in this study, LLLT had a positive systemic effect on the early stages of bone formation.
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