Objective: This study assessed the effect of diode laser 808nm low-level laser therapy (LLLT) on oral mucous wound healing for immunosuppressed rabbits under corticosteroid therapy. Material and Methods: Twenty-four adult male New Zealand White rabbits were subjected to Immunosupression via dexamethasone injection, the animals were subjected to equal surgical incisions in oral mucous membrane in both sides. The left side was irradiated with Diode laser 808nm with average power 100mw for three minutes per session (18 Joule), animals were subjected to three laser sessions per week. Soft tissue specimens were collected after 0, 4, 7, 10, and 14 days and stained with Hematoxylin-Eosin, as well as Masson’s Trichrome. Results: Fibroblast proliferation was significantly more evident in the laser irradiated groups, also there was a marked and significant increase in mitotic activity with hyperplasia of the prickle cell layer as well as formation of fibro vascular tissue in the underlying tissue in the same groups. Concluosion: Under the circumstances of this experiment we can conclude that diode laser 808nm LLLT can accelerate wound healing in immunosuppressed experimental rabbits.