Lateral Epicondylitis (LE) is generally a work related or sports related pain disorder usually caused by excessive quick, monotonous, repetitive eccentric contractions and gripping activities of wrist. The aim of the study was to compare the effects of Mulligan’s mobilization with movement with ultrasound and between Mulligan’s mobilization with movement with low level laser therapy in lateral epicondylitis. Setting: Govt Wenlock Hospital and Dr M.V.Shetty Surgical Nursing Home,Mangalore. Materials and Methods: Quasi experimental study includes 40 diagnosed and referred tennis elbow subjects divided into two groups, Group A and Group B. Group A received Mulligan’s mobilization with movement with ultrasound while group B received Mulligan’s mobilization with movement with low level laser therapy. Patients in the age group of 25-60 yrs were recruited for the study. The pre and post test values of the VAS and grip strength was assessed following the interventions. The collective data was analyzed by paired and unpaired‘t’ test. Results: There was a highly significant difference existing in group A and group B in the visual analogue scale and grip strength. But in group A which received Mulligan’s mobilization with movement along with ultrasound, there was a highly significant difference as compared to group A in reducing pain whereas the grip strength improved in group B subjects which received Mulligan’s mobilization with movement along with low level laser therapy. Conclusion Mulligan’s mobilization with movement along with ultrasound helps in reducing pain whereas Mulligan’s mobilization with movement along with low level laser therapy helps in improving the grip strength in lateral epicondylitis